Development of certified reference material of methamphetamine hydrochloride

Authors

  • Silvia Regina Pinheiro Lopes National Institute of Metrology, Quality and Technology (Inmetro)
  • Wagner Wollinger
  • Eliane Cristina Pires do Rego
  • Bruno Carius Garrido

DOI:

https://doi.org/10.21014/actaimeko.v14i3.2008

Keywords:

Methamphetamine, certified reference material, metrological traceability, forensic chemistry

Abstract

This work aimed to present the production of a Certified Reference Material (CRM) of methamphetamine hydrochloride, as an important tool to ensure the quality of forensic results. Methamphetamine is a synthetic drug derived from amphetamine, which potentially stimulates the central nervous system, and its prolonged use can cause excessive anxiety, euphoria, bipolar disorder, and psychosis, among other health damages. To produce this batch of CRM, homogeneity and transport stability studies were carried out by High-Performance Liquid Chromatography with Photodiode Array Detection (HPLC-PDA) using the results of chromatographic area corrected by the mass fraction of the sample in the analyzed solution. Evaluation of stability under storage conditions and characterization of the material were performed by 1H qNMR, a ratio primary measurement procedure. The CRM showed neither considerable heterogeneity nor a tendency to instability under transport conditions (temperature of 50 °C up to 21 days) and storage conditions (20–25 °C). The certified purity value of methamphetamine hydrochloride was (999 ± 12) mg/g, equivalent to a mass fraction of (99.9 ± 1.2) g / (100 g), (k = 2).

Downloads

Published

2025-08-02

Issue

Vol. 14 No. 3 (2025)

Section

Research Papers

License

Copyright (c) 2025 Silvia Regina Pinheiro Lopes, Wagner Wollinger , Eliane Cristina Pires do Rego, Bruno Carius Garrido

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under the CC BY 4.0, Creative Commons Attribution 4.0 International License.

Users are free to

  • share, i.e. copy and redistribute the material in any medium or format for any purpose, even commercially;
  • adapt, i.e. remix, transform, and build upon the material for any purpose, even commercially.

At the same time, the user must give appropriate credit, provide a link to the license, and indicate if changes were made.
Additional information about the license can be found at: https://creativecommons.org/licenses/by/4.0/.

Authors are

  • able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).