Production and certification of a reference material of selenium enriched yeast

Authors

  • Márcia Silva da Rocha Labin, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, 25250-020, Brazil
  • Lilian da Silva Labin, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, 25250-020, Brazil
  • Jefferson R. Souza Labin, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, 25250-020, Brazil
  • Lucas J. Carvalho Labor, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, 25250-020, Brazil
  • Rodrigo V. P. Leal Labor, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, 25250-020, Brazil
  • Thiago O. Araujo Labin, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, 25250-020, Brazil
  • Marcelo D. Almeida Labin, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, 25250-020, Brazil
  • Rodrigo C. Sena Labin, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, 25250-020, Brazil
  • Janaína M. R. Caixeiro Dquim, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, 25250-020, Brazil

DOI:

https://doi.org/10.21014/actaimeko.v15i1.1976

Keywords:

selenium, selenomethionine, enriched yeast, CRM production

Abstract

Certified Reference Materials (CRMs) are indispensable for ensuring food safety, playing a fundamental role in method development, validation, and both internal and external quality assurance. Given the growing consumption of selenium-based dietary supplements and the associated health risks of improper dosage, the availability of specific CRMs is crucial for regulatory compliance and consumer protection. This study presents the production and certification process of a selenium-enriched yeast reference material. The certification of this CRM (CRM 8969.0001) was conducted by the Inorganic Analysis Laboratory (Labin) of the National Institute of Metrology, Quality and Technology (Inmetro). The work comprises the procedures for batch preparation, homogeneity assessment, stability studies, and material characterisation. The certified values are: total selenium (Se) at (2637 ± 139) mg/kg and selenomethionine (SeMet) at (3248 ± 325) mg/kg. This CRM provides a critical tool for Brazilian manufacturers and analytical laboratories to ensure the quality and safety of selenium supplements.

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Published

2026-02-26

Issue

Vol. 15 No. 1 (2026)

Section

Research Papers

License

Copyright (c) 2026 Márcia Silva da Rocha, Lilian da Silva, Jefferson R. Souza, Lucas J. Carvalho, Rodrigo V. P. Leal, Thiago O. Araujo, Marcelo D. Almeida, Rodrigo C. Sena, Janaína M. R. Caixeiro

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