Strategies for the design of additively manufactured nanocomposite scaffolds for hard tissue regeneration

Authors

  • Pierpaolo Fucile Department of Advanced Biomedical Sciences, University of Naples Federico II, 80125 Naples, Italy
  • Ilaria Onofrio Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80125 Naples, Italy
  • Ida Papallo Department of Advanced Biomedical Sciences, University of Naples Federico II, 80125 Naples, Italy
  • Vito Gallicchio Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80125 Naples, Italy
  • Andrea Rega Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80125 Naples, Italy
  • Vincenzo D'Antò Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80125 Naples, Italy
  • Giovanni Improta Department of Public Health, University of Naples Federico II, 80125 Naples, Italy
  • Roberto De Santis Institute of Polymers, Composites and Biomaterials – National Research Council of Italy, 80125 Naples, Italy
  • Antonio Gloria Institute of Polymers, Composites and Biomaterials – National Research Council of Italy, 80125 Naples, Italy
  • Teresa Russo Institute of Polymers, Composites and Biomaterials – National Research Council of Italy, 80125 Naples, Italy

DOI:

https://doi.org/10.21014/acta_imeko.v9i4.739

Abstract

Additive manufacturing represents a powerful tool for the direct fabrication of lightweight and porous structures with tuneable properties. In this study, a fused deposition modelling/3D fibre deposition technique was considered for designing 3D nanocomposite scaffolds with specific architectures and tailored biological, mechanical, and mass transport properties. 3D poly(caprolactone) (PCL)/hydroxyapatite (HA) nanocomposite scaffolds were designed for bone tissue engineering. An optimisation design strategy for the additive manufacturing processes based on extrusion/injection methods was at first extended to the development of the PCL/HA scaffolds. Further insight into the effect of the process parameters on the mechanical properties and morphological features of the nanocomposite scaffolds was provided. The nanocomposite structures were analysed at different levels, and the possibility of designing 3D customised scaffolds for mandibular defect regeneration (i.e., symphysis and ramus) was also reported.

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Published

2020-12-17

Issue

Vol. 9 No. 4 (2020)

Section

Research Papers

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